• Almost all previously published haplotype association studie

  2020-08-06

  

  Almost all previously published haplotype association studies have demonstrated the importance of haplotype reconstruction because the combinations of SNPs exert synergistic effects on protein function. Even synonymous polymorphisms within haplotypes can have functional consequences that are drastic

• Serine phosphorylation is thought to be one of the

  2020-08-05

  

  Serine 129 phosphorylation is thought to be one of the most important posttranslational modifications of αSyn. One of the principal observations in this study is that the phosphorylation (S129) of αSyn was observably potentiated in 6- and 9-month-old σ1R−/− mice. The level of phosphor-αSyn in dopami

• Marine sponges are organisms naturally rich in collagens

  2020-08-05

  

  Marine sponges are organisms naturally rich in collagens whose features are peculiar if compared to their vertebrate counterparts (Garrone et al., 1975). Sponges are an interesting alternative to the classical bovine and porcine sources for the extraction of these molecules, and their exploitation i

• br Acknowledgments This work is supported by

  2020-08-05

  

  Acknowledgments This work is supported by grants from the Singapore National Medical Research Council (R-713-000-181-511) and the Ministry of Education (R-713-000-169-112) and by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excel

• Metakaolin is the product of

  2020-08-05

  

  Metakaolin is the product of calcination of kaolinite rich clay at temperatures between 600 and 850 °C [11], [12] depending on the purity and the crystallinity of the initial clay. The geopolymers from metakaolin as aluminosilicate source have shown promising results in previous works [13], [14], [1

• RING type dimers are generally

  2020-08-04

  

  RING-type dimers are generally formed in one of two ways: 1) sequences outside the RING are primarily responsible for dimerization; or 2) the RING per se is responsible for dimerization. In both types, the two RINGs are positioned such that the E2 binding surfaces face away from each other (see Fig.

• The heteroaromatic fused derivatives with furan or

  2020-08-04

  

  The heteroaromatic fused derivatives with furan or thiophene developed by Brañas and co-workers demonstrate increased antitumor activity. In fact, heteroaromatic rings likely contribute to additional interactions such as Van der Waals forces. Qian and co-workers have described a novel family of naph

• Henderson et al have demonstrated that montelukast

  2020-08-04

  

  Henderson et al. have demonstrated that montelukast blockade of CysLT1 receptors improves airway remodeling, including airway goblet cell metaplasia, smooth muscle cell layer thickening, and subepithelial fibrosis in a mouse model of asthma. The histological findings of this study revealed a thicken

• Within the X CX PX RX motif

  2020-08-04

  

  Within the X1CX3PX5RX7 motif of several prokaryotic FGE substrates, the residues of X3, X5, and X7 are variably found as mixtures of alanine, glycine, threonine, or serine residues [26], [27]. The docked model of our identified HCTPRRP motif revealed that position X1 (H1) and position X7 (P7) were n

• IRAK inhibitor 1 synthesis br Abbreviations br Introduction

  2020-08-04

  

  Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III

• Both meiotic COs and NCOs require

  2020-08-04

  

  Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε

• In our previous study we showed

  2020-08-04

  

  In our previous study we showed that normal and cancerous Thymidine of kidney exhibit the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Furthermore, the activity of class I ADH isoenzymes and total ADH were significantly higher in cancer tissue than in unchanged renal cells. Moreove

• br Results and discussion br

  2020-08-03

  

  Results and discussion Conclusions A total of 3 ambient variables and 6 flow- and temperature-related operating variables were considered to develop Cox regression models for the four transitional statuses and their degree of significance was examined by their hazard ratios. The temperature of

• Selective inhibitor of phosphodiesterase type PDE I is

  2020-08-03

  

  Selective inhibitor of phosphodiesterase type 5 (PDE5I) is commonly used for ED treatment. PDE5I exhibits its vasodilatory effect by inhibiting the degradation of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle and allows increased blood flow for penile tumescence. Udenafil (D

• The prostaglandin E receptors PTGER PTGER PTGER and PTGER

  2020-08-03

  

  The prostaglandin E receptors PTGER1, PTGER2, PTGER3 and PTGER4 are believed to play a proinflammatory role in BL [127]. In particular, PTGER4 has been identified on a variety of B cell lymphoblast cell lines, including BL, and is thought to inactivate NF-κB to sensitize cells to chemotherapeutics a

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